ElfQuest would make a good MMORPG- (though I'd like to think you could have a lot Holts/Villiages ect. (a.k.a Clans on most other games) and keep it cool. Perhaps having roleplay be a HUGE part of the game, hunting and even bonding with animals, I mean cooking and magic and well being an elf no matter what the tribe with a bunc of other REAL people who also enjoy ElfQuest would be very good.
It'd also make a cool console game with similar elements- make it The Sims (2) like and you'd have the makings for a good game... though I'm all for having 'random' events in the game to make life a little more interesting I'd love to be able to 'set things in motion' too.
On that note, I also think a Statistical Japanese RPG (Final Fantasy) might not work to well with ElfQuest and yet it would. I'll elaborate on this more when I have time.