Comics to Video Games have never had a series of success *sans the Sandbox vrs of Spiderman + Spiderman 2* So i'm overall very against the idea of a EQ game.
The best thing I can come up with, is a special scenario. Due to PC's Various rules *no killing for sport, hunting and surviving* we should pick a situation that the wolfriders were in that involved lots of adventure and situations where they had no other choice?
The Shard Series maybe?
Think about it, you could have steath options to sneak past humans *MSG, Thief* combined with fairly accurate intense storyline to regain the shattered palace shards.
And finally, since the pack splits up so much. You could maintain several different storylines and it would be wonderful.
Now I have no idea how appropriately this would be executed *FPS* *Marvel Avengers style* Honestly I rather it not happen.
But still, the little fanboy part of me does get a bit tingly thinking about controlling cutters wolf as he jumps from citadel roof-top to roof-top.